Amitryptyline, Demethyl-
Amitryptyline, Demethyl- Brand names, Amitryptyline, Demethyl- Analogs
- AVENTYL HCL
- Acetexa
- Allegron
- Altilev
- Amitryptyline, Demethyl-
- Ateben
- Avantyl
- Aventyl
- Demethylamitriptylene
- Demethylamitriptyline
- Demethylamitryptyline
- Desitriptilina
- Desmethylamitriptyline
- Lumbeck
- Noramitriptyline
- Noritren
- Nortrilen
- Nortriptyline Hcl
- Nortryptiline
- Norzepine
- PAMELOR
- Psychostyl
- Sensaval
- Sensival Ventyl
- Sesaval
- Vividyl
Amitryptyline, Demethyl- Brand Names Mixture
- No information avaliable
Amitryptyline, Demethyl- Chemical_Formula
C19H21N
Amitryptyline, Demethyl- RX_link
http://www.rxlist.com/cgi/generic/nortrip.htm
Amitryptyline, Demethyl- fda sheet
Amitryptyline, Demethyl- msds (material safety sheet)
Amitryptyline, Demethyl- Synthesis Reference
E. I. Engelhardt, U.S. Pat. 3,922,305 (1975)
Amitryptyline, Demethyl- Molecular Weight
263.377 g/mol
Amitryptyline, Demethyl- Melting Point
213-215oC
Amitryptyline, Demethyl- H2O Solubility
No information avaliable
Amitryptyline, Demethyl- State
Solid
Amitryptyline, Demethyl- LogP
4.298
Amitryptyline, Demethyl- Dosage Forms
Capsules
Amitryptyline, Demethyl- Indication
For the treatment of depression.
Amitryptyline, Demethyl- Pharmacology
Similar to protriptyline, nortriptyline is a tricyclic antidepressant of the dibenzocycloheptene type and is the active metabolite of amitriptyline.
Amitryptyline, Demethyl- Absorption
Well absorbed from the GI tract.
Amitryptyline, Demethyl- side effects and Toxicity
Symptoms of overdose include cardiac dysrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. LD50=mg/kg(orally in rat)
Amitryptyline, Demethyl- Patient Information
Amitryptyline, Demethyl- Organisms Affected
Humans and other mammals
