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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C19H21N
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RX_link
http://www.rxlist.com/cgi/generic/nortrip.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
E. I. Engelhardt, U.S. Pat. 3,922,305 (1975)
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Molecular Weight
263.377 g/mol
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Melting Point
213-215oC
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H2O Solubility
No information avaliable
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State
Solid
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LogP
4.298
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Dosage Forms
Capsules
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Indication
For the treatment of depression.
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Pharmacology
Similar to protriptyline, nortriptyline is a tricyclic antidepressant of the dibenzocycloheptene type and is the active metabolite of amitriptyline.
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Absorption
Well absorbed from the GI tract.
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side effects and Toxicity
Symptoms of overdose include cardiac dysrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. LD50=mg/kg(orally in rat)
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Patient Information
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Organisms Affected
Humans and other mammals