Avantyl
Brand names,
Avantyl
Analogs
Avantyl
Brand Names Mixture
Avantyl
Chemical_Formula
C19H21N
Avantyl
RX_link
http://www.rxlist.com/cgi/generic/nortrip.htm
Avantyl
fda sheet
Avantyl
msds (material safety sheet)
Avantyl
Synthesis Reference
E. I. Engelhardt, U.S. Pat. 3,922,305 (1975)
Avantyl
Molecular Weight
263.377 g/mol
Avantyl
Melting Point
213-215oC
Avantyl
H2O Solubility
No information avaliable
Avantyl
State
Solid
Avantyl
LogP
4.298
Avantyl
Dosage Forms
Capsules
Avantyl
Indication
For the treatment of depression.
Avantyl
Pharmacology
Similar to protriptyline, nortriptyline is a tricyclic antidepressant of the dibenzocycloheptene type and is the active metabolite of amitriptyline.
Avantyl
Absorption
Well absorbed from the GI tract.
Avantyl
side effects and Toxicity
Symptoms of overdose include cardiac dysrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, and CNS depression, including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. LD50=mg/kg(orally in rat)
Avantyl
Patient Information
Avantyl
Organisms Affected
Humans and other mammals