Categorie
Isoptin
Les marques,
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Analogs
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Les marques melange
Tarka (trandolapril + verapamil hydrochloride)
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Formule chimique
C27H38N2O4
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RX lien
http://www.rxlist.com/cgi/generic/verapsr.htm
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FDA fiche
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msds (fiche de securite des materiaux)
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Synthese de reference
Dengel, le brevet américain. 3,261,859 (1966)
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Poids moleculaire
454.602 g/mol
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Point de fusion
< 25 oC
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H2O Solubilite
4,47 mg / L
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Etat
Liquid
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LogP
5.931
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Formes pharmaceutiques
Capsule (libération prolongée); liquide; Solution; Tablet; Tablet (libération prolongée)
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Indication
Pour le traitement de l'hypertension et l'angine.
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Pharmacologie
Vérapamil, un anti-arythmique de classe IV agent, est utilisé comme un blocage des canaux calciques (BCC) agent pour le traitement de l'angine, l'hypertension, et pour tachyarythmies supraventriculaires.
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Absorption
90%
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Toxicite
DL50 = 8 mg / kg (iv chez la souris)
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Information pour les patients
Verapamil HCl is known as a calcium channel blocker. It is taken to treat high blood pressure, to relieve some
chest pains in patients with angina, or to treat some problems with heart rhythms. Verapamil has several drug
interactions, make sure your physician and pharmacist known all the medicines you are taking so they may properly
advise you. Verapamil HCl is excreted in breast milk. It may be necessary to change therapy or provide an alternate
to breast milk. The most common side effect is constipation. This may be relieved with dietary modification (more
fiber) or laxatives. Sustained release tablets should be taken with food. They should not be broken or crushed. Doses
may need some adjustment, make sure to have your condition monitored regularly.
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Organismes affectes
Les humains et autres mammifères