Calan SR
Brand names,
Calan SR
Analogs
Calan SR
Brand Names Mixture
- Tarka (trandolapril + verapamil hydrochloride)
Calan SR
Chemical_Formula
C27H38N2O4
Calan SR
RX_link
http://www.rxlist.com/cgi/generic/verapsr.htm
Calan SR
fda sheet
Calan SR
msds (material safety sheet)
Calan SR
Synthesis Reference
Dengel, U.S. Pat. 3,261,859 (1966)
Calan SR
Molecular Weight
454.602 g/mol
Calan SR
Melting Point
< 25 oC
Calan SR
H2O Solubility
4.47 mg/L
Calan SR
State
Liquid
Calan SR
LogP
5.931
Calan SR
Dosage Forms
Capsule (sustained-release); Liquid; Solution; Tablet; Tablet (extended-release)
Calan SR
Indication
For the treatment of hypertension and angina.
Calan SR
Pharmacology
Verapamil, a class IV antiarrhythmic agent, is used as a calcium-channel blocking (CCB) agent for the treatment of angina, hypertension, and for supraventricular tachyarrhythmias.
Calan SR
Absorption
90%
Calan SR
side effects and Toxicity
LD50=8 mg/kg (i.v. in mice)
Calan SR
Patient Information
Verapamil HCl is known as a calcium channel blocker. It is taken to treat high blood pressure, to relieve some
chest pains in patients with angina, or to treat some problems with heart rhythms. Verapamil has several drug
interactions, make sure your physician and pharmacist known all the medicines you are taking so they may properly
advise you. Verapamil HCl is excreted in breast milk. It may be necessary to change therapy or provide an alternate
to breast milk. The most common side effect is constipation. This may be relieved with dietary modification (more
fiber) or laxatives. Sustained release tablets should be taken with food. They should not be broken or crushed. Doses
may need some adjustment, make sure to have your condition monitored regularly.
Calan SR
Organisms Affected
Humans and other mammals