Apo-Verap
Brand names,
Apo-Verap
Analogs
Apo-Verap
Brand Names Mixture
- Tarka (trandolapril + verapamil hydrochloride)
Apo-Verap
Chemical_Formula
C27H38N2O4
Apo-Verap
RX_link
http://www.rxlist.com/cgi/generic/verapsr.htm
Apo-Verap
fda sheet
Apo-Verap
msds (material safety sheet)
Apo-Verap
Synthesis Reference
Dengel, U.S. Pat. 3,261,859 (1966)
Apo-Verap
Molecular Weight
454.602 g/mol
Apo-Verap
Melting Point
< 25 oC
Apo-Verap
H2O Solubility
4.47 mg/L
Apo-Verap
State
Liquid
Apo-Verap
LogP
5.931
Apo-Verap
Dosage Forms
Capsule (sustained-release); Liquid; Solution; Tablet; Tablet (extended-release)
Apo-Verap
Indication
For the treatment of hypertension and angina.
Apo-Verap
Pharmacology
Verapamil, a class IV antiarrhythmic agent, is used as a calcium-channel blocking (CCB) agent for the treatment of angina, hypertension, and for supraventricular tachyarrhythmias.
Apo-Verap
Absorption
90%
Apo-Verap
side effects and Toxicity
LD50=8 mg/kg (i.v. in mice)
Apo-Verap
Patient Information
Verapamil HCl is known as a calcium channel blocker. It is taken to treat high blood pressure, to relieve some
chest pains in patients with angina, or to treat some problems with heart rhythms. Verapamil has several drug
interactions, make sure your physician and pharmacist known all the medicines you are taking so they may properly
advise you. Verapamil HCl is excreted in breast milk. It may be necessary to change therapy or provide an alternate
to breast milk. The most common side effect is constipation. This may be relieved with dietary modification (more
fiber) or laxatives. Sustained release tablets should be taken with food. They should not be broken or crushed. Doses
may need some adjustment, make sure to have your condition monitored regularly.
Apo-Verap
Organisms Affected
Humans and other mammals