Isoptimo
Brand names,
Isoptimo
Analogs
Isoptimo
Brand Names Mixture
- Tarka (trandolapril + verapamil hydrochloride)
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Chemical_Formula
C27H38N2O4
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RX_link
http://www.rxlist.com/cgi/generic/verapsr.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Dengel, U.S. Pat. 3,261,859 (1966)
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Molecular Weight
454.602 g/mol
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Melting Point
< 25 oC
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H2O Solubility
4.47 mg/L
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State
Liquid
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LogP
5.931
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Dosage Forms
Capsule (sustained-release); Liquid; Solution; Tablet; Tablet (extended-release)
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Indication
For the treatment of hypertension and angina.
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Pharmacology
Verapamil, a class IV antiarrhythmic agent, is used as a calcium-channel blocking (CCB) agent for the treatment of angina, hypertension, and for supraventricular tachyarrhythmias.
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Absorption
90%
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side effects and Toxicity
LD50=8 mg/kg (i.v. in mice)
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Patient Information
Verapamil HCl is known as a calcium channel blocker. It is taken to treat high blood pressure, to relieve some
chest pains in patients with angina, or to treat some problems with heart rhythms. Verapamil has several drug
interactions, make sure your physician and pharmacist known all the medicines you are taking so they may properly
advise you. Verapamil HCl is excreted in breast milk. It may be necessary to change therapy or provide an alternate
to breast milk. The most common side effect is constipation. This may be relieved with dietary modification (more
fiber) or laxatives. Sustained release tablets should be taken with food. They should not be broken or crushed. Doses
may need some adjustment, make sure to have your condition monitored regularly.
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Organisms Affected
Humans and other mammals