Iproveratril
Brand names,
Iproveratril
Analogs
Iproveratril
Brand Names Mixture
- Tarka (trandolapril + verapamil hydrochloride)
Iproveratril
Chemical_Formula
C27H38N2O4
Iproveratril
RX_link
http://www.rxlist.com/cgi/generic/verapsr.htm
Iproveratril
fda sheet
Iproveratril
msds (material safety sheet)
Iproveratril
Synthesis Reference
Dengel, U.S. Pat. 3,261,859 (1966)
Iproveratril
Molecular Weight
454.602 g/mol
Iproveratril
Melting Point
< 25 oC
Iproveratril
H2O Solubility
4.47 mg/L
Iproveratril
State
Liquid
Iproveratril
LogP
5.931
Iproveratril
Dosage Forms
Capsule (sustained-release); Liquid; Solution; Tablet; Tablet (extended-release)
Iproveratril
Indication
For the treatment of hypertension and angina.
Iproveratril
Pharmacology
Verapamil, a class IV antiarrhythmic agent, is used as a calcium-channel blocking (CCB) agent for the treatment of angina, hypertension, and for supraventricular tachyarrhythmias.
Iproveratril
Absorption
90%
Iproveratril
side effects and Toxicity
LD50=8 mg/kg (i.v. in mice)
Iproveratril
Patient Information
Verapamil HCl is known as a calcium channel blocker. It is taken to treat high blood pressure, to relieve some
chest pains in patients with angina, or to treat some problems with heart rhythms. Verapamil has several drug
interactions, make sure your physician and pharmacist known all the medicines you are taking so they may properly
advise you. Verapamil HCl is excreted in breast milk. It may be necessary to change therapy or provide an alternate
to breast milk. The most common side effect is constipation. This may be relieved with dietary modification (more
fiber) or laxatives. Sustained release tablets should be taken with food. They should not be broken or crushed. Doses
may need some adjustment, make sure to have your condition monitored regularly.
Iproveratril
Organisms Affected
Humans and other mammals