Arpamyl
Brand names,
Arpamyl
Analogs
Arpamyl
Brand Names Mixture
- Tarka (trandolapril + verapamil hydrochloride)
Arpamyl
Chemical_Formula
C27H38N2O4
Arpamyl
RX_link
http://www.rxlist.com/cgi/generic/verapsr.htm
Arpamyl
fda sheet
Arpamyl
msds (material safety sheet)
Arpamyl
Synthesis Reference
Dengel, U.S. Pat. 3,261,859 (1966)
Arpamyl
Molecular Weight
454.602 g/mol
Arpamyl
Melting Point
< 25 oC
Arpamyl
H2O Solubility
4.47 mg/L
Arpamyl
State
Liquid
Arpamyl
LogP
5.931
Arpamyl
Dosage Forms
Capsule (sustained-release); Liquid; Solution; Tablet; Tablet (extended-release)
Arpamyl
Indication
For the treatment of hypertension and angina.
Arpamyl
Pharmacology
Verapamil, a class IV antiarrhythmic agent, is used as a calcium-channel blocking (CCB) agent for the treatment of angina, hypertension, and for supraventricular tachyarrhythmias.
Arpamyl
Absorption
90%
Arpamyl
side effects and Toxicity
LD50=8 mg/kg (i.v. in mice)
Arpamyl
Patient Information
Verapamil HCl is known as a calcium channel blocker. It is taken to treat high blood pressure, to relieve some
chest pains in patients with angina, or to treat some problems with heart rhythms. Verapamil has several drug
interactions, make sure your physician and pharmacist known all the medicines you are taking so they may properly
advise you. Verapamil HCl is excreted in breast milk. It may be necessary to change therapy or provide an alternate
to breast milk. The most common side effect is constipation. This may be relieved with dietary modification (more
fiber) or laxatives. Sustained release tablets should be taken with food. They should not be broken or crushed. Doses
may need some adjustment, make sure to have your condition monitored regularly.
Arpamyl
Organisms Affected
Humans and other mammals