Verelan PM
Brand names,
Verelan PM
Analogs
Verelan PM
Brand Names Mixture
- Tarka (trandolapril + verapamil hydrochloride)
Verelan PM
Chemical_Formula
C27H38N2O4
Verelan PM
RX_link
http://www.rxlist.com/cgi/generic/verapsr.htm
Verelan PM
fda sheet
Verelan PM
msds (material safety sheet)
Verelan PM
Synthesis Reference
Dengel, U.S. Pat. 3,261,859 (1966)
Verelan PM
Molecular Weight
454.602 g/mol
Verelan PM
Melting Point
< 25 oC
Verelan PM
H2O Solubility
4.47 mg/L
Verelan PM
State
Liquid
Verelan PM
LogP
5.931
Verelan PM
Dosage Forms
Capsule (sustained-release); Liquid; Solution; Tablet; Tablet (extended-release)
Verelan PM
Indication
For the treatment of hypertension and angina.
Verelan PM
Pharmacology
Verapamil, a class IV antiarrhythmic agent, is used as a calcium-channel blocking (CCB) agent for the treatment of angina, hypertension, and for supraventricular tachyarrhythmias.
Verelan PM
Absorption
90%
Verelan PM
side effects and Toxicity
LD50=8 mg/kg (i.v. in mice)
Verelan PM
Patient Information
Verapamil HCl is known as a calcium channel blocker. It is taken to treat high blood pressure, to relieve some
chest pains in patients with angina, or to treat some problems with heart rhythms. Verapamil has several drug
interactions, make sure your physician and pharmacist known all the medicines you are taking so they may properly
advise you. Verapamil HCl is excreted in breast milk. It may be necessary to change therapy or provide an alternate
to breast milk. The most common side effect is constipation. This may be relieved with dietary modification (more
fiber) or laxatives. Sustained release tablets should be taken with food. They should not be broken or crushed. Doses
may need some adjustment, make sure to have your condition monitored regularly.
Verelan PM
Organisms Affected
Humans and other mammals