Vibra-Tabs
Brand names,
Vibra-Tabs
Analogs
Vibra-Tabs
Brand Names Mixture
Vibra-Tabs
Chemical_Formula
C22H24N2O8
Vibra-Tabs
RX_link
http://www.rxlist.com/cgi/generic/doxycyc.htm
Vibra-Tabs
fda sheet
Vibra-Tabs
msds (material safety sheet)
Vibra-Tabs
Synthesis Reference
C. R. Stephens et al.; J. Am. Chem. Soc. 80; 5324 (1958)
Vibra-Tabs
Molecular Weight
444.435 g/mol
Vibra-Tabs
Melting Point
201 oC
Vibra-Tabs
H2O Solubility
630 mg/L
Vibra-Tabs
State
Solid
Vibra-Tabs
LogP
-1.219
Vibra-Tabs
Dosage Forms
Tablet; Capsule; Gel; Liquid; Powder; Powder for solution
Vibra-Tabs
Indication
For the treatment of the following infections:Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae, Chancroid caused by Haemophilus ducreyi, Uncomplicated gonorrhea caused by Neisseria gonorrhoeae, Respiratory tract infections caused by Mycoplasma pneumoniae or Streptococcus pneumoniae. Lymphogranuloma ve
Vibra-Tabs
Pharmacology
Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis.
Vibra-Tabs
Absorption
completely absorbed after oral administration
Vibra-Tabs
side effects and Toxicity
anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region. skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg(i.p. in rat)
Vibra-Tabs
Patient Information
Vibra-Tabs
Organisms Affected
Enteric bacteria and other eubacteria