Doxytec
Brand names,
Doxytec
Analogs
Doxytec
Brand Names Mixture
Doxytec
Chemical_Formula
C22H24N2O8
Doxytec
RX_link
http://www.rxlist.com/cgi/generic/doxycyc.htm
Doxytec
fda sheet
Doxytec
msds (material safety sheet)
Doxytec
Synthesis Reference
C. R. Stephens et al.; J. Am. Chem. Soc. 80; 5324 (1958)
Doxytec
Molecular Weight
444.435 g/mol
Doxytec
Melting Point
201 oC
Doxytec
H2O Solubility
630 mg/L
Doxytec
State
Solid
Doxytec
LogP
-1.219
Doxytec
Dosage Forms
Tablet; Capsule; Gel; Liquid; Powder; Powder for solution
Doxytec
Indication
For the treatment of the following infections:Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae, Chancroid caused by Haemophilus ducreyi, Uncomplicated gonorrhea caused by Neisseria gonorrhoeae, Respiratory tract infections caused by Mycoplasma pneumoniae or Streptococcus pneumoniae. Lymphogranuloma ve
Doxytec
Pharmacology
Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis.
Doxytec
Absorption
completely absorbed after oral administration
Doxytec
side effects and Toxicity
anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region. skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg(i.p. in rat)
Doxytec
Patient Information
Doxytec
Organisms Affected
Enteric bacteria and other eubacteria