Doxycycline Hyclate
Brand names,
Doxycycline Hyclate
Analogs
Doxycycline Hyclate
Brand Names Mixture
Doxycycline Hyclate
Chemical_Formula
C22H24N2O8
Doxycycline Hyclate
RX_link
http://www.rxlist.com/cgi/generic/doxycyc.htm
Doxycycline Hyclate
fda sheet
Doxycycline Hyclate
msds (material safety sheet)
Doxycycline Hyclate
Synthesis Reference
C. R. Stephens et al.; J. Am. Chem. Soc. 80; 5324 (1958)
Doxycycline Hyclate
Molecular Weight
444.435 g/mol
Doxycycline Hyclate
Melting Point
201 oC
Doxycycline Hyclate
H2O Solubility
630 mg/L
Doxycycline Hyclate
State
Solid
Doxycycline Hyclate
LogP
-1.219
Doxycycline Hyclate
Dosage Forms
Tablet; Capsule; Gel; Liquid; Powder; Powder for solution
Doxycycline Hyclate
Indication
For the treatment of the following infections:Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae, Chancroid caused by Haemophilus ducreyi, Uncomplicated gonorrhea caused by Neisseria gonorrhoeae, Respiratory tract infections caused by Mycoplasma pneumoniae or Streptococcus pneumoniae. Lymphogranuloma ve
Doxycycline Hyclate
Pharmacology
Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis.
Doxycycline Hyclate
Absorption
completely absorbed after oral administration
Doxycycline Hyclate
side effects and Toxicity
anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region. skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg(i.p. in rat)
Doxycycline Hyclate
Patient Information
Doxycycline Hyclate
Organisms Affected
Enteric bacteria and other eubacteria