Supracyclin
Brand names,
Supracyclin
Analogs
Supracyclin
Brand Names Mixture
Supracyclin
Chemical_Formula
C22H24N2O8
Supracyclin
RX_link
http://www.rxlist.com/cgi/generic/doxycyc.htm
Supracyclin
fda sheet
Supracyclin
msds (material safety sheet)
Supracyclin
Synthesis Reference
C. R. Stephens et al.; J. Am. Chem. Soc. 80; 5324 (1958)
Supracyclin
Molecular Weight
444.435 g/mol
Supracyclin
Melting Point
201 oC
Supracyclin
H2O Solubility
630 mg/L
Supracyclin
State
Solid
Supracyclin
LogP
-1.219
Supracyclin
Dosage Forms
Tablet; Capsule; Gel; Liquid; Powder; Powder for solution
Supracyclin
Indication
For the treatment of the following infections:Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae, Chancroid caused by Haemophilus ducreyi, Uncomplicated gonorrhea caused by Neisseria gonorrhoeae, Respiratory tract infections caused by Mycoplasma pneumoniae or Streptococcus pneumoniae. Lymphogranuloma ve
Supracyclin
Pharmacology
Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis.
Supracyclin
Absorption
completely absorbed after oral administration
Supracyclin
side effects and Toxicity
anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region. skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg(i.p. in rat)
Supracyclin
Patient Information
Supracyclin
Organisms Affected
Enteric bacteria and other eubacteria