Novo-Doxylin
Brand names,
Novo-Doxylin
Analogs
Novo-Doxylin
Brand Names Mixture
Novo-Doxylin
Chemical_Formula
C22H24N2O8
Novo-Doxylin
RX_link
http://www.rxlist.com/cgi/generic/doxycyc.htm
Novo-Doxylin
fda sheet
Novo-Doxylin
msds (material safety sheet)
Novo-Doxylin
Synthesis Reference
C. R. Stephens et al.; J. Am. Chem. Soc. 80; 5324 (1958)
Novo-Doxylin
Molecular Weight
444.435 g/mol
Novo-Doxylin
Melting Point
201 oC
Novo-Doxylin
H2O Solubility
630 mg/L
Novo-Doxylin
State
Solid
Novo-Doxylin
LogP
-1.219
Novo-Doxylin
Dosage Forms
Tablet; Capsule; Gel; Liquid; Powder; Powder for solution
Novo-Doxylin
Indication
For the treatment of the following infections:Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae, Chancroid caused by Haemophilus ducreyi, Uncomplicated gonorrhea caused by Neisseria gonorrhoeae, Respiratory tract infections caused by Mycoplasma pneumoniae or Streptococcus pneumoniae. Lymphogranuloma ve
Novo-Doxylin
Pharmacology
Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis.
Novo-Doxylin
Absorption
completely absorbed after oral administration
Novo-Doxylin
side effects and Toxicity
anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region. skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg(i.p. in rat)
Novo-Doxylin
Patient Information
Novo-Doxylin
Organisms Affected
Enteric bacteria and other eubacteria