Apo-Doxy
Brand names,
Apo-Doxy
Analogs
Apo-Doxy
Brand Names Mixture
Apo-Doxy
Chemical_Formula
C22H24N2O8
Apo-Doxy
RX_link
http://www.rxlist.com/cgi/generic/doxycyc.htm
Apo-Doxy
fda sheet
Apo-Doxy
msds (material safety sheet)
Apo-Doxy
Synthesis Reference
C. R. Stephens et al.; J. Am. Chem. Soc. 80; 5324 (1958)
Apo-Doxy
Molecular Weight
444.435 g/mol
Apo-Doxy
Melting Point
201 oC
Apo-Doxy
H2O Solubility
630 mg/L
Apo-Doxy
State
Solid
Apo-Doxy
LogP
-1.219
Apo-Doxy
Dosage Forms
Tablet; Capsule; Gel; Liquid; Powder; Powder for solution
Apo-Doxy
Indication
For the treatment of the following infections:Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae, Chancroid caused by Haemophilus ducreyi, Uncomplicated gonorrhea caused by Neisseria gonorrhoeae, Respiratory tract infections caused by Mycoplasma pneumoniae or Streptococcus pneumoniae. Lymphogranuloma ve
Apo-Doxy
Pharmacology
Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis.
Apo-Doxy
Absorption
completely absorbed after oral administration
Apo-Doxy
side effects and Toxicity
anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region. skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg(i.p. in rat)
Apo-Doxy
Patient Information
Apo-Doxy
Organisms Affected
Enteric bacteria and other eubacteria