Doxychel
Brand names,
Doxychel
Analogs
Doxychel
Brand Names Mixture
Doxychel
Chemical_Formula
C22H24N2O8
Doxychel
RX_link
http://www.rxlist.com/cgi/generic/doxycyc.htm
Doxychel
fda sheet
Doxychel
msds (material safety sheet)
Doxychel
Synthesis Reference
C. R. Stephens et al.; J. Am. Chem. Soc. 80; 5324 (1958)
Doxychel
Molecular Weight
444.435 g/mol
Doxychel
Melting Point
201 oC
Doxychel
H2O Solubility
630 mg/L
Doxychel
State
Solid
Doxychel
LogP
-1.219
Doxychel
Dosage Forms
Tablet; Capsule; Gel; Liquid; Powder; Powder for solution
Doxychel
Indication
For the treatment of the following infections:Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae, Chancroid caused by Haemophilus ducreyi, Uncomplicated gonorrhea caused by Neisseria gonorrhoeae, Respiratory tract infections caused by Mycoplasma pneumoniae or Streptococcus pneumoniae. Lymphogranuloma ve
Doxychel
Pharmacology
Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis.
Doxychel
Absorption
completely absorbed after oral administration
Doxychel
side effects and Toxicity
anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region. skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg(i.p. in rat)
Doxychel
Patient Information
Doxychel
Organisms Affected
Enteric bacteria and other eubacteria