DOXCYCLINE ANHYDROUS
Brand names,
DOXCYCLINE ANHYDROUS
Analogs
DOXCYCLINE ANHYDROUS
Brand Names Mixture
DOXCYCLINE ANHYDROUS
Chemical_Formula
C22H24N2O8
DOXCYCLINE ANHYDROUS
RX_link
http://www.rxlist.com/cgi/generic/doxycyc.htm
DOXCYCLINE ANHYDROUS
fda sheet
DOXCYCLINE ANHYDROUS
msds (material safety sheet)
DOXCYCLINE ANHYDROUS
Synthesis Reference
C. R. Stephens et al.; J. Am. Chem. Soc. 80; 5324 (1958)
DOXCYCLINE ANHYDROUS
Molecular Weight
444.435 g/mol
DOXCYCLINE ANHYDROUS
Melting Point
201 oC
DOXCYCLINE ANHYDROUS
H2O Solubility
630 mg/L
DOXCYCLINE ANHYDROUS
State
Solid
DOXCYCLINE ANHYDROUS
LogP
-1.219
DOXCYCLINE ANHYDROUS
Dosage Forms
Tablet; Capsule; Gel; Liquid; Powder; Powder for solution
DOXCYCLINE ANHYDROUS
Indication
For the treatment of the following infections:Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae, Chancroid caused by Haemophilus ducreyi, Uncomplicated gonorrhea caused by Neisseria gonorrhoeae, Respiratory tract infections caused by Mycoplasma pneumoniae or Streptococcus pneumoniae. Lymphogranuloma ve
DOXCYCLINE ANHYDROUS
Pharmacology
Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis.
DOXCYCLINE ANHYDROUS
Absorption
completely absorbed after oral administration
DOXCYCLINE ANHYDROUS
side effects and Toxicity
anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region. skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg(i.p. in rat)
DOXCYCLINE ANHYDROUS
Patient Information
DOXCYCLINE ANHYDROUS
Organisms Affected
Enteric bacteria and other eubacteria