Doxycycline Monohydrate
Brand names,
Doxycycline Monohydrate
Analogs
Doxycycline Monohydrate
Brand Names Mixture
Doxycycline Monohydrate
Chemical_Formula
C22H24N2O8
Doxycycline Monohydrate
RX_link
http://www.rxlist.com/cgi/generic/doxycyc.htm
Doxycycline Monohydrate
fda sheet
Doxycycline Monohydrate
msds (material safety sheet)
Doxycycline Monohydrate
Synthesis Reference
C. R. Stephens et al.; J. Am. Chem. Soc. 80; 5324 (1958)
Doxycycline Monohydrate
Molecular Weight
444.435 g/mol
Doxycycline Monohydrate
Melting Point
201 oC
Doxycycline Monohydrate
H2O Solubility
630 mg/L
Doxycycline Monohydrate
State
Solid
Doxycycline Monohydrate
LogP
-1.219
Doxycycline Monohydrate
Dosage Forms
Tablet; Capsule; Gel; Liquid; Powder; Powder for solution
Doxycycline Monohydrate
Indication
For the treatment of the following infections:Rocky mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers caused by Rickettsiae, Chancroid caused by Haemophilus ducreyi, Uncomplicated gonorrhea caused by Neisseria gonorrhoeae, Respiratory tract infections caused by Mycoplasma pneumoniae or Streptococcus pneumoniae. Lymphogranuloma ve
Doxycycline Monohydrate
Pharmacology
Doxycycline, a long-acting tetracycline derived from oxytetracycline, is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with COPD, and adult periodontitis.
Doxycycline Monohydrate
Absorption
completely absorbed after oral administration
Doxycycline Monohydrate
side effects and Toxicity
anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region. skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg(i.p. in rat)
Doxycycline Monohydrate
Patient Information
Doxycycline Monohydrate
Organisms Affected
Enteric bacteria and other eubacteria