Verophen
Brand names,
Verophen
Analogs
Verophen
Brand Names Mixture
Verophen
Chemical_Formula
C17H20N2S
Verophen
RX_link
No information avaliable
Verophen
fda sheet
Verophen
msds (material safety sheet)
Verophen
Synthesis Reference
No information avaliable
Verophen
Molecular Weight
284.42 g/mol
Verophen
Melting Point
< 25 oC
Verophen
H2O Solubility
14.2 mg/L
Verophen
State
Liquid
Verophen
LogP
4.893
Verophen
Dosage Forms
Tablet; Oral liquid; Injection
Verophen
Indication
Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.
Verophen
Pharmacology
Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Promazine hydrochloride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness. Promazine has weak extrapyramidal and autonomic side effects which lead to its use in the elderly, for restless or psychotic patients. Its anti-psychotic effect is also weaker and it is not useful in general psychiatry.
Verophen
Absorption
Absorption may be erratic and peak plasma concentrations show large interindividual differences.
Verophen
side effects and Toxicity
Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.
Verophen
Patient Information
No information avaliable
Verophen
Organisms Affected
Humans and other mammals