Elmarin
Brand names,
Elmarin
Analogs
Elmarin
Brand Names Mixture
Elmarin
Chemical_Formula
C17H20N2S
Elmarin
RX_link
No information avaliable
Elmarin
fda sheet
Elmarin
msds (material safety sheet)
Elmarin
Synthesis Reference
No information avaliable
Elmarin
Molecular Weight
284.42 g/mol
Elmarin
Melting Point
< 25 oC
Elmarin
H2O Solubility
14.2 mg/L
Elmarin
State
Liquid
Elmarin
LogP
4.893
Elmarin
Dosage Forms
Tablet; Oral liquid; Injection
Elmarin
Indication
Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.
Elmarin
Pharmacology
Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Promazine hydrochloride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness. Promazine has weak extrapyramidal and autonomic side effects which lead to its use in the elderly, for restless or psychotic patients. Its anti-psychotic effect is also weaker and it is not useful in general psychiatry.
Elmarin
Absorption
Absorption may be erratic and peak plasma concentrations show large interindividual differences.
Elmarin
side effects and Toxicity
Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.
Elmarin
Patient Information
No information avaliable
Elmarin
Organisms Affected
Humans and other mammals