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Megaphen Brand names, Megaphen Analogs

Megaphen Brand Names Mixture

  • No information avaliable

Megaphen Chemical_Formula


Megaphen RX_link

No information avaliable

Megaphen fda sheet

Megaphen msds (material safety sheet)

Megaphen Synthesis Reference

No information avaliable

Megaphen Molecular Weight

284.42 g/mol

Megaphen Melting Point

< 25 oC

Megaphen H2O Solubility

14.2 mg/L

Megaphen State


Megaphen LogP


Megaphen Dosage Forms

Tablet; Oral liquid; Injection

Megaphen Indication

Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.

Megaphen Pharmacology

Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Promazine hydrochloride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness. Promazine has weak extrapyramidal and autonomic side effects which lead to its use in the elderly, for restless or psychotic patients. Its anti-psychotic effect is also weaker and it is not useful in general psychiatry.

Megaphen Absorption

Absorption may be erratic and peak plasma concentrations show large interindividual differences.

Megaphen side effects and Toxicity

Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.

Megaphen Patient Information

No information avaliable

Megaphen Organisms Affected

Humans and other mammals