Promwill
Brand names,
Promwill
Analogs
Promwill
Brand Names Mixture
Promwill
Chemical_Formula
C17H20N2S
Promwill
RX_link
No information avaliable
Promwill
fda sheet
Promwill
msds (material safety sheet)
Promwill
Synthesis Reference
No information avaliable
Promwill
Molecular Weight
284.42 g/mol
Promwill
Melting Point
< 25 oC
Promwill
H2O Solubility
14.2 mg/L
Promwill
State
Liquid
Promwill
LogP
4.893
Promwill
Dosage Forms
Tablet; Oral liquid; Injection
Promwill
Indication
Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.
Promwill
Pharmacology
Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Promazine hydrochloride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness. Promazine has weak extrapyramidal and autonomic side effects which lead to its use in the elderly, for restless or psychotic patients. Its anti-psychotic effect is also weaker and it is not useful in general psychiatry.
Promwill
Absorption
Absorption may be erratic and peak plasma concentrations show large interindividual differences.
Promwill
side effects and Toxicity
Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.
Promwill
Patient Information
No information avaliable
Promwill
Organisms Affected
Humans and other mammals