Promazine Hcl
Brand names,
Promazine Hcl
Analogs
Promazine Hcl
Brand Names Mixture
Promazine Hcl
Chemical_Formula
C17H20N2S
Promazine Hcl
RX_link
No information avaliable
Promazine Hcl
fda sheet
Promazine Hcl
msds (material safety sheet)
Promazine Hcl
Synthesis Reference
No information avaliable
Promazine Hcl
Molecular Weight
284.42 g/mol
Promazine Hcl
Melting Point
< 25 oC
Promazine Hcl
H2O Solubility
14.2 mg/L
Promazine Hcl
State
Liquid
Promazine Hcl
LogP
4.893
Promazine Hcl
Dosage Forms
Tablet; Oral liquid; Injection
Promazine Hcl
Indication
Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.
Promazine Hcl
Pharmacology
Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Promazine hydrochloride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness. Promazine has weak extrapyramidal and autonomic side effects which lead to its use in the elderly, for restless or psychotic patients. Its anti-psychotic effect is also weaker and it is not useful in general psychiatry.
Promazine Hcl
Absorption
Absorption may be erratic and peak plasma concentrations show large interindividual differences.
Promazine Hcl
side effects and Toxicity
Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.
Promazine Hcl
Patient Information
No information avaliable
Promazine Hcl
Organisms Affected
Humans and other mammals