Ampliactil
Brand names,
Ampliactil
Analogs
Ampliactil
Brand Names Mixture
Ampliactil
Chemical_Formula
C17H20N2S
Ampliactil
RX_link
No information avaliable
Ampliactil
fda sheet
Ampliactil
msds (material safety sheet)
Ampliactil
Synthesis Reference
No information avaliable
Ampliactil
Molecular Weight
284.42 g/mol
Ampliactil
Melting Point
< 25 oC
Ampliactil
H2O Solubility
14.2 mg/L
Ampliactil
State
Liquid
Ampliactil
LogP
4.893
Ampliactil
Dosage Forms
Tablet; Oral liquid; Injection
Ampliactil
Indication
Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.
Ampliactil
Pharmacology
Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Promazine hydrochloride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness. Promazine has weak extrapyramidal and autonomic side effects which lead to its use in the elderly, for restless or psychotic patients. Its anti-psychotic effect is also weaker and it is not useful in general psychiatry.
Ampliactil
Absorption
Absorption may be erratic and peak plasma concentrations show large interindividual differences.
Ampliactil
side effects and Toxicity
Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.
Ampliactil
Patient Information
No information avaliable
Ampliactil
Organisms Affected
Humans and other mammals