Romtiazin
Brand names,
Romtiazin
Analogs
Romtiazin
Brand Names Mixture
Romtiazin
Chemical_Formula
C17H20N2S
Romtiazin
RX_link
No information avaliable
Romtiazin
fda sheet
Romtiazin
msds (material safety sheet)
Romtiazin
Synthesis Reference
No information avaliable
Romtiazin
Molecular Weight
284.42 g/mol
Romtiazin
Melting Point
< 25 oC
Romtiazin
H2O Solubility
14.2 mg/L
Romtiazin
State
Liquid
Romtiazin
LogP
4.893
Romtiazin
Dosage Forms
Tablet; Oral liquid; Injection
Romtiazin
Indication
Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.
Romtiazin
Pharmacology
Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Promazine hydrochloride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness. Promazine has weak extrapyramidal and autonomic side effects which lead to its use in the elderly, for restless or psychotic patients. Its anti-psychotic effect is also weaker and it is not useful in general psychiatry.
Romtiazin
Absorption
Absorption may be erratic and peak plasma concentrations show large interindividual differences.
Romtiazin
side effects and Toxicity
Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.
Romtiazin
Patient Information
No information avaliable
Romtiazin
Organisms Affected
Humans and other mammals