Novomazina
Brand names,
Novomazina
Analogs
Novomazina
Brand Names Mixture
Novomazina
Chemical_Formula
C17H20N2S
Novomazina
RX_link
No information avaliable
Novomazina
fda sheet
Novomazina
msds (material safety sheet)
Novomazina
Synthesis Reference
No information avaliable
Novomazina
Molecular Weight
284.42 g/mol
Novomazina
Melting Point
< 25 oC
Novomazina
H2O Solubility
14.2 mg/L
Novomazina
State
Liquid
Novomazina
LogP
4.893
Novomazina
Dosage Forms
Tablet; Oral liquid; Injection
Novomazina
Indication
Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.
Novomazina
Pharmacology
Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Promazine hydrochloride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness. Promazine has weak extrapyramidal and autonomic side effects which lead to its use in the elderly, for restless or psychotic patients. Its anti-psychotic effect is also weaker and it is not useful in general psychiatry.
Novomazina
Absorption
Absorption may be erratic and peak plasma concentrations show large interindividual differences.
Novomazina
side effects and Toxicity
Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.
Novomazina
Patient Information
No information avaliable
Novomazina
Organisms Affected
Humans and other mammals