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Phenothiazine Brand names, Phenothiazine Analogs

Phenothiazine Brand Names Mixture

  • No information avaliable

Phenothiazine Chemical_Formula


Phenothiazine RX_link

No information avaliable

Phenothiazine fda sheet

Phenothiazine msds (material safety sheet)

Phenothiazine Synthesis Reference

No information avaliable

Phenothiazine Molecular Weight

284.42 g/mol

Phenothiazine Melting Point

< 25 oC

Phenothiazine H2O Solubility

14.2 mg/L

Phenothiazine State


Phenothiazine LogP


Phenothiazine Dosage Forms

Tablet; Oral liquid; Injection

Phenothiazine Indication

Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.

Phenothiazine Pharmacology

Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Promazine hydrochloride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness. Promazine has weak extrapyramidal and autonomic side effects which lead to its use in the elderly, for restless or psychotic patients. Its anti-psychotic effect is also weaker and it is not useful in general psychiatry.

Phenothiazine Absorption

Absorption may be erratic and peak plasma concentrations show large interindividual differences.

Phenothiazine side effects and Toxicity

Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.

Phenothiazine Patient Information

No information avaliable

Phenothiazine Organisms Affected

Humans and other mammals