Phenothiazine
Phenothiazine Brand names, Phenothiazine Analogs
- AB
- Aminazin
- Aminazine
- Ampazine
- Ampliactil
- Amplictil
- Berophen
- CPZ
- Chlor-Promanyl
- Chlordelazin
- Chlorderazin
- Chlorpromados
- Chlorpromazine Hcl
- Chlorpromazine Hcl Intensol
- Chlropromados
- Contomin
- Elmarin
- Esmind
- Esparin
- Fenactil
- Fenaktyl
- Fraction
- Largactil
- Largactilothiazine
- Largactyl
- Liranol
- Megaphen
- Neo-Hibernex
- Novomazina
- Phenactyl
- Phenothiazine
- Prazin
- Prazine
- Proma
- Promactil
- Promapar
- Promazil
- Promazin
- Promazina
- Promazine Hcl
- Promwill
- Propaphenin
- Protactyl
- Prozil
- Psychozine
- Romtiazin
- Sanopron
- Sinophenin
- Sonazine
- Sparine
- Thorazine
- Tomil
- Torazina
- Verophen
- Vesprin
- Wintermin
Phenothiazine Brand Names Mixture
- No information avaliable
Phenothiazine Chemical_Formula
C17H20N2S
Phenothiazine RX_link
No information avaliable
Phenothiazine fda sheet
Phenothiazine msds (material safety sheet)
Phenothiazine Synthesis Reference
No information avaliable
Phenothiazine Molecular Weight
284.42 g/mol
Phenothiazine Melting Point
< 25 oC
Phenothiazine H2O Solubility
14.2 mg/L
Phenothiazine State
Liquid
Phenothiazine LogP
4.893
Phenothiazine Dosage Forms
Tablet; Oral liquid; Injection
Phenothiazine Indication
Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.
Phenothiazine Pharmacology
Promazine belongs to a group of medications known as the phenothiazine antipsychotics. It acts by blocking a variety of receptors in the brain, particularly dopamine receptors. Dopamine is involved in transmitting signals between brain cells. When there is an excess amount of dopamine in the brain it causes over-stimulation of dopamine receptors. These receptors normally act to modify behaviour and over-stimulation may result in psychotic illness. Promazine hydrochloride blocks these receptors and stops them becoming over-stimulated, thereby helping to control psychotic illness. Promazine has weak extrapyramidal and autonomic side effects which lead to its use in the elderly, for restless or psychotic patients. Its anti-psychotic effect is also weaker and it is not useful in general psychiatry.
Phenothiazine Absorption
Absorption may be erratic and peak plasma concentrations show large interindividual differences.
Phenothiazine side effects and Toxicity
Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.
Phenothiazine Patient Information
No information avaliable
Phenothiazine Organisms Affected
Humans and other mammals
