Verapamil
Brand names,
Verapamil
Analogs
Verapamil
Brand Names Mixture
- Tarka (trandolapril + verapamil hydrochloride)
Verapamil
Chemical_Formula
C27H38N2O4
Verapamil
RX_link
http://www.rxlist.com/cgi/generic/verapsr.htm
Verapamil
fda sheet
Verapamil
msds (material safety sheet)
Verapamil
Synthesis Reference
Dengel, U.S. Pat. 3,261,859 (1966)
Verapamil
Molecular Weight
454.602 g/mol
Verapamil
Melting Point
< 25 oC
Verapamil
H2O Solubility
4.47 mg/L
Verapamil
State
Liquid
Verapamil
LogP
5.931
Verapamil
Dosage Forms
Capsule (sustained-release); Liquid; Solution; Tablet; Tablet (extended-release)
Verapamil
Indication
For the treatment of hypertension and angina.
Verapamil
Pharmacology
Verapamil, a class IV antiarrhythmic agent, is used as a calcium-channel blocking (CCB) agent for the treatment of angina, hypertension, and for supraventricular tachyarrhythmias.
Verapamil
Absorption
90%
Verapamil
side effects and Toxicity
LD50=8 mg/kg (i.v. in mice)
Verapamil
Patient Information
Verapamil HCl is known as a calcium channel blocker. It is taken to treat high blood pressure, to relieve some
chest pains in patients with angina, or to treat some problems with heart rhythms. Verapamil has several drug
interactions, make sure your physician and pharmacist known all the medicines you are taking so they may properly
advise you. Verapamil HCl is excreted in breast milk. It may be necessary to change therapy or provide an alternate
to breast milk. The most common side effect is constipation. This may be relieved with dietary modification (more
fiber) or laxatives. Sustained release tablets should be taken with food. They should not be broken or crushed. Doses
may need some adjustment, make sure to have your condition monitored regularly.
Verapamil
Organisms Affected
Humans and other mammals