Trazodone Hcl en es it fr

Trazodone Hcl Brand names, Trazodone Hcl Analogs

Trazodone Hcl Brand Names Mixture

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Trazodone Hcl Chemical_Formula


Trazodone Hcl RX_link

Trazodone Hcl fda sheet

Trazodone_Hcl FDA

Trazodone Hcl msds (material safety sheet)

Trazodone Hcl Synthesis Reference

Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)

Trazodone Hcl Molecular Weight

371.864 g/mol

Trazodone Hcl Melting Point

86-87 oC

Trazodone Hcl H2O Solubility

Sparigly soluble

Trazodone Hcl State


Trazodone Hcl LogP


Trazodone Hcl Dosage Forms


Trazodone Hcl Indication

For the treatment of depression.

Trazodone Hcl Pharmacology

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.

Trazodone Hcl Absorption

Well absorbed following oral administration.

Trazodone Hcl side effects and Toxicity

LD50=96mg/kg (i.v. in mice)

Trazodone Hcl Patient Information

Trazodone Hcl Organisms Affected

Humans and other mammals