Desirel
Desirel Brand names, Desirel Analogs
Desirel Brand Names Mixture
- No information avaliable
Desirel Chemical_Formula
C19H22ClN5O
Desirel RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Desirel fda sheet
Desirel msds (material safety sheet)
Desirel Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Desirel Molecular Weight
371.864 g/mol
Desirel Melting Point
86-87 oC
Desirel H2O Solubility
Sparigly soluble
Desirel State
Solid
Desirel LogP
2.553
Desirel Dosage Forms
Tablet
Desirel Indication
For the treatment of depression.
Desirel Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Desirel Absorption
Well absorbed following oral administration.
Desirel side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Desirel Patient Information
Desirel Organisms Affected
Humans and other mammals
