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Desirel Brand names, Desirel Analogs

Desirel Brand Names Mixture

  • No information avaliable

Desirel Chemical_Formula


Desirel RX_link

Desirel fda sheet

Desirel FDA

Desirel msds (material safety sheet)

Desirel Synthesis Reference

Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)

Desirel Molecular Weight

371.864 g/mol

Desirel Melting Point

86-87 oC

Desirel H2O Solubility

Sparigly soluble

Desirel State


Desirel LogP


Desirel Dosage Forms


Desirel Indication

For the treatment of depression.

Desirel Pharmacology

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.

Desirel Absorption

Well absorbed following oral administration.

Desirel side effects and Toxicity

LD50=96mg/kg (i.v. in mice)

Desirel Patient Information

Desirel Organisms Affected

Humans and other mammals