Trazolan
Trazolan Brand names, Trazolan Analogs
Trazolan Brand Names Mixture
- No information avaliable
Trazolan Chemical_Formula
C19H22ClN5O
Trazolan RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Trazolan fda sheet
Trazolan msds (material safety sheet)
Trazolan Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Trazolan Molecular Weight
371.864 g/mol
Trazolan Melting Point
86-87 oC
Trazolan H2O Solubility
Sparigly soluble
Trazolan State
Solid
Trazolan LogP
2.553
Trazolan Dosage Forms
Tablet
Trazolan Indication
For the treatment of depression.
Trazolan Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Trazolan Absorption
Well absorbed following oral administration.
Trazolan side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Trazolan Patient Information
Trazolan Organisms Affected
Humans and other mammals
