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Trazolan Brand names, Trazolan Analogs

Trazolan Brand Names Mixture

  • No information avaliable

Trazolan Chemical_Formula


Trazolan RX_link

Trazolan fda sheet

Trazolan FDA

Trazolan msds (material safety sheet)

Trazolan Synthesis Reference

Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)

Trazolan Molecular Weight

371.864 g/mol

Trazolan Melting Point

86-87 oC

Trazolan H2O Solubility

Sparigly soluble

Trazolan State


Trazolan LogP


Trazolan Dosage Forms


Trazolan Indication

For the treatment of depression.

Trazolan Pharmacology

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.

Trazolan Absorption

Well absorbed following oral administration.

Trazolan side effects and Toxicity

LD50=96mg/kg (i.v. in mice)

Trazolan Patient Information

Trazolan Organisms Affected

Humans and other mammals