Sideril
Sideril Brand names, Sideril Analogs
Sideril Brand Names Mixture
- No information avaliable
Sideril Chemical_Formula
C19H22ClN5O
Sideril RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Sideril fda sheet
Sideril msds (material safety sheet)
Sideril Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Sideril Molecular Weight
371.864 g/mol
Sideril Melting Point
86-87 oC
Sideril H2O Solubility
Sparigly soluble
Sideril State
Solid
Sideril LogP
2.553
Sideril Dosage Forms
Tablet
Sideril Indication
For the treatment of depression.
Sideril Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Sideril Absorption
Well absorbed following oral administration.
Sideril side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Sideril Patient Information
Sideril Organisms Affected
Humans and other mammals
