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Desyrel Brand names, Desyrel Analogs

Desyrel Brand Names Mixture

  • No information avaliable

Desyrel Chemical_Formula


Desyrel RX_link

Desyrel fda sheet

Desyrel FDA

Desyrel msds (material safety sheet)

Desyrel Synthesis Reference

Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)

Desyrel Molecular Weight

371.864 g/mol

Desyrel Melting Point

86-87 oC

Desyrel H2O Solubility

Sparigly soluble

Desyrel State


Desyrel LogP


Desyrel Dosage Forms


Desyrel Indication

For the treatment of depression.

Desyrel Pharmacology

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.

Desyrel Absorption

Well absorbed following oral administration.

Desyrel side effects and Toxicity

LD50=96mg/kg (i.v. in mice)

Desyrel Patient Information

Desyrel Organisms Affected

Humans and other mammals