Desyrel
Desyrel Brand names, Desyrel Analogs
Desyrel Brand Names Mixture
- No information avaliable
Desyrel Chemical_Formula
C19H22ClN5O
Desyrel RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Desyrel fda sheet
Desyrel msds (material safety sheet)
Desyrel Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Desyrel Molecular Weight
371.864 g/mol
Desyrel Melting Point
86-87 oC
Desyrel H2O Solubility
Sparigly soluble
Desyrel State
Solid
Desyrel LogP
2.553
Desyrel Dosage Forms
Tablet
Desyrel Indication
For the treatment of depression.
Desyrel Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Desyrel Absorption
Well absorbed following oral administration.
Desyrel side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Desyrel Patient Information
Desyrel Organisms Affected
Humans and other mammals
