Thombran

• Antidepressants, Second-Generation
• Anti-anxiety Agents
• Serotonin Uptake Inhibitors
• ATC:N06AX05

• Beneficat
• Bimaran
• Desirel
• Desyrel
• Molipaxin
• Pragmazone
• Sideril
• Thombran
• Tombran
• Trazalon
• Trazodil
• Trazodon
• Trazodona [Inn-Spanish]
• Trazodona [Spanish]
• Trazodone Hcl
• Trazodone Hydrochloride
• Trazodonum [Inn-Latin]
• Trazodonum [Latin]
• Trazolan
• Trazonil
• Trialodine
• Trittico

• No information avaliable

C₁₉H₂₂ClN₅O

http://www.rxlist.com/cgi/generic/traz.htm

Thombran FDA

Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)

371.864 g/mol

86-87 ^oC

Sparigly soluble

Solid

2.553

Tablet

For the treatment of depression.

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.

Well absorbed following oral administration.

LD₅₀=96mg/kg (i.v. in mice)

Humans and other mammals