Thombran
Thombran Brand names, Thombran Analogs
Thombran Brand Names Mixture
- No information avaliable
Thombran Chemical_Formula
C19H22ClN5O
Thombran RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Thombran fda sheet
Thombran msds (material safety sheet)
Thombran Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Thombran Molecular Weight
371.864 g/mol
Thombran Melting Point
86-87 oC
Thombran H2O Solubility
Sparigly soluble
Thombran State
Solid
Thombran LogP
2.553
Thombran Dosage Forms
Tablet
Thombran Indication
For the treatment of depression.
Thombran Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Thombran Absorption
Well absorbed following oral administration.
Thombran side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Thombran Patient Information
Thombran Organisms Affected
Humans and other mammals
