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Thombran Brand names, Thombran Analogs

Thombran Brand Names Mixture

  • No information avaliable

Thombran Chemical_Formula


Thombran RX_link

Thombran fda sheet

Thombran FDA

Thombran msds (material safety sheet)

Thombran Synthesis Reference

Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)

Thombran Molecular Weight

371.864 g/mol

Thombran Melting Point

86-87 oC

Thombran H2O Solubility

Sparigly soluble

Thombran State


Thombran LogP


Thombran Dosage Forms


Thombran Indication

For the treatment of depression.

Thombran Pharmacology

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.

Thombran Absorption

Well absorbed following oral administration.

Thombran side effects and Toxicity

LD50=96mg/kg (i.v. in mice)

Thombran Patient Information

Thombran Organisms Affected

Humans and other mammals