Tombran
Tombran Brand names, Tombran Analogs
Tombran Brand Names Mixture
- No information avaliable
Tombran Chemical_Formula
C19H22ClN5O
Tombran RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Tombran fda sheet
Tombran msds (material safety sheet)
Tombran Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Tombran Molecular Weight
371.864 g/mol
Tombran Melting Point
86-87 oC
Tombran H2O Solubility
Sparigly soluble
Tombran State
Solid
Tombran LogP
2.553
Tombran Dosage Forms
Tablet
Tombran Indication
For the treatment of depression.
Tombran Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Tombran Absorption
Well absorbed following oral administration.
Tombran side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Tombran Patient Information
Tombran Organisms Affected
Humans and other mammals
