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Tombran Brand names, Tombran Analogs

Tombran Brand Names Mixture

  • No information avaliable

Tombran Chemical_Formula


Tombran RX_link

Tombran fda sheet

Tombran FDA

Tombran msds (material safety sheet)

Tombran Synthesis Reference

Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)

Tombran Molecular Weight

371.864 g/mol

Tombran Melting Point

86-87 oC

Tombran H2O Solubility

Sparigly soluble

Tombran State


Tombran LogP


Tombran Dosage Forms


Tombran Indication

For the treatment of depression.

Tombran Pharmacology

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.

Tombran Absorption

Well absorbed following oral administration.

Tombran side effects and Toxicity

LD50=96mg/kg (i.v. in mice)

Tombran Patient Information

Tombran Organisms Affected

Humans and other mammals