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Pragmazone Brand names, Pragmazone Analogs

Pragmazone Brand Names Mixture

  • No information avaliable

Pragmazone Chemical_Formula


Pragmazone RX_link

Pragmazone fda sheet

Pragmazone FDA

Pragmazone msds (material safety sheet)

Pragmazone Synthesis Reference

Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)

Pragmazone Molecular Weight

371.864 g/mol

Pragmazone Melting Point

86-87 oC

Pragmazone H2O Solubility

Sparigly soluble

Pragmazone State


Pragmazone LogP


Pragmazone Dosage Forms


Pragmazone Indication

For the treatment of depression.

Pragmazone Pharmacology

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.

Pragmazone Absorption

Well absorbed following oral administration.

Pragmazone side effects and Toxicity

LD50=96mg/kg (i.v. in mice)

Pragmazone Patient Information

Pragmazone Organisms Affected

Humans and other mammals