Pragmazone
Pragmazone Brand names, Pragmazone Analogs
Pragmazone Brand Names Mixture
- No information avaliable
Pragmazone Chemical_Formula
C19H22ClN5O
Pragmazone RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Pragmazone fda sheet
Pragmazone msds (material safety sheet)
Pragmazone Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Pragmazone Molecular Weight
371.864 g/mol
Pragmazone Melting Point
86-87 oC
Pragmazone H2O Solubility
Sparigly soluble
Pragmazone State
Solid
Pragmazone LogP
2.553
Pragmazone Dosage Forms
Tablet
Pragmazone Indication
For the treatment of depression.
Pragmazone Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Pragmazone Absorption
Well absorbed following oral administration.
Pragmazone side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Pragmazone Patient Information
Pragmazone Organisms Affected
Humans and other mammals
