Bimaran
Bimaran Brand names, Bimaran Analogs
Bimaran Brand Names Mixture
- No information avaliable
Bimaran Chemical_Formula
C19H22ClN5O
Bimaran RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Bimaran fda sheet
Bimaran msds (material safety sheet)
Bimaran Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Bimaran Molecular Weight
371.864 g/mol
Bimaran Melting Point
86-87 oC
Bimaran H2O Solubility
Sparigly soluble
Bimaran State
Solid
Bimaran LogP
2.553
Bimaran Dosage Forms
Tablet
Bimaran Indication
For the treatment of depression.
Bimaran Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Bimaran Absorption
Well absorbed following oral administration.
Bimaran side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Bimaran Patient Information
Bimaran Organisms Affected
Humans and other mammals
