Trazodon
Trazodon Brand names, Trazodon Analogs
Trazodon Brand Names Mixture
- No information avaliable
Trazodon Chemical_Formula
C19H22ClN5O
Trazodon RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Trazodon fda sheet
Trazodon msds (material safety sheet)
Trazodon Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Trazodon Molecular Weight
371.864 g/mol
Trazodon Melting Point
86-87 oC
Trazodon H2O Solubility
Sparigly soluble
Trazodon State
Solid
Trazodon LogP
2.553
Trazodon Dosage Forms
Tablet
Trazodon Indication
For the treatment of depression.
Trazodon Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Trazodon Absorption
Well absorbed following oral administration.
Trazodon side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Trazodon Patient Information
Trazodon Organisms Affected
Humans and other mammals
