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Trazodon Brand names, Trazodon Analogs

Trazodon Brand Names Mixture

  • No information avaliable

Trazodon Chemical_Formula


Trazodon RX_link

Trazodon fda sheet

Trazodon FDA

Trazodon msds (material safety sheet)

Trazodon Synthesis Reference

Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)

Trazodon Molecular Weight

371.864 g/mol

Trazodon Melting Point

86-87 oC

Trazodon H2O Solubility

Sparigly soluble

Trazodon State


Trazodon LogP


Trazodon Dosage Forms


Trazodon Indication

For the treatment of depression.

Trazodon Pharmacology

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.

Trazodon Absorption

Well absorbed following oral administration.

Trazodon side effects and Toxicity

LD50=96mg/kg (i.v. in mice)

Trazodon Patient Information

Trazodon Organisms Affected

Humans and other mammals