Trittico
Trittico Brand names, Trittico Analogs
Trittico Brand Names Mixture
- No information avaliable
Trittico Chemical_Formula
C19H22ClN5O
Trittico RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Trittico fda sheet
Trittico msds (material safety sheet)
Trittico Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Trittico Molecular Weight
371.864 g/mol
Trittico Melting Point
86-87 oC
Trittico H2O Solubility
Sparigly soluble
Trittico State
Solid
Trittico LogP
2.553
Trittico Dosage Forms
Tablet
Trittico Indication
For the treatment of depression.
Trittico Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Trittico Absorption
Well absorbed following oral administration.
Trittico side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Trittico Patient Information
Trittico Organisms Affected
Humans and other mammals
