Beneficat
Beneficat Brand names, Beneficat Analogs
Beneficat Brand Names Mixture
- No information avaliable
Beneficat Chemical_Formula
C19H22ClN5O
Beneficat RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Beneficat fda sheet
Beneficat msds (material safety sheet)
Beneficat Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Beneficat Molecular Weight
371.864 g/mol
Beneficat Melting Point
86-87 oC
Beneficat H2O Solubility
Sparigly soluble
Beneficat State
Solid
Beneficat LogP
2.553
Beneficat Dosage Forms
Tablet
Beneficat Indication
For the treatment of depression.
Beneficat Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Beneficat Absorption
Well absorbed following oral administration.
Beneficat side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Beneficat Patient Information
Beneficat Organisms Affected
Humans and other mammals
