Trazodil
Trazodil Brand names, Trazodil Analogs
Trazodil Brand Names Mixture
- No information avaliable
Trazodil Chemical_Formula
C19H22ClN5O
Trazodil RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Trazodil fda sheet
Trazodil msds (material safety sheet)
Trazodil Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Trazodil Molecular Weight
371.864 g/mol
Trazodil Melting Point
86-87 oC
Trazodil H2O Solubility
Sparigly soluble
Trazodil State
Solid
Trazodil LogP
2.553
Trazodil Dosage Forms
Tablet
Trazodil Indication
For the treatment of depression.
Trazodil Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Trazodil Absorption
Well absorbed following oral administration.
Trazodil side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Trazodil Patient Information
Trazodil Organisms Affected
Humans and other mammals
