Trazodil
Brand names,
Trazodil
Analogs
Trazodil
Brand Names Mixture
Trazodil
Chemical_Formula
C19H22ClN5O
Trazodil
RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Trazodil
fda sheet
Trazodil
msds (material safety sheet)
Trazodil
Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Trazodil
Molecular Weight
371.864 g/mol
Trazodil
Melting Point
86-87 oC
Trazodil
H2O Solubility
Sparigly soluble
Trazodil
State
Solid
Trazodil
LogP
2.553
Trazodil
Dosage Forms
Tablet
Trazodil
Indication
For the treatment of depression.
Trazodil
Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Trazodil
Absorption
Well absorbed following oral administration.
Trazodil
side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Trazodil
Patient Information
Trazodil
Organisms Affected
Humans and other mammals