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Trazodil Brand names, Trazodil Analogs

Trazodil Brand Names Mixture

  • No information avaliable

Trazodil Chemical_Formula


Trazodil RX_link

Trazodil fda sheet

Trazodil FDA

Trazodil msds (material safety sheet)

Trazodil Synthesis Reference

Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)

Trazodil Molecular Weight

371.864 g/mol

Trazodil Melting Point

86-87 oC

Trazodil H2O Solubility

Sparigly soluble

Trazodil State


Trazodil LogP


Trazodil Dosage Forms


Trazodil Indication

For the treatment of depression.

Trazodil Pharmacology

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.

Trazodil Absorption

Well absorbed following oral administration.

Trazodil side effects and Toxicity

LD50=96mg/kg (i.v. in mice)

Trazodil Patient Information

Trazodil Organisms Affected

Humans and other mammals