Trazonil
Brand names,
Trazonil
Analogs
Trazonil
Brand Names Mixture
Trazonil
Chemical_Formula
C19H22ClN5O
Trazonil
RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Trazonil
fda sheet
Trazonil
msds (material safety sheet)
Trazonil
Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Trazonil
Molecular Weight
371.864 g/mol
Trazonil
Melting Point
86-87 oC
Trazonil
H2O Solubility
Sparigly soluble
Trazonil
State
Solid
Trazonil
LogP
2.553
Trazonil
Dosage Forms
Tablet
Trazonil
Indication
For the treatment of depression.
Trazonil
Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Trazonil
Absorption
Well absorbed following oral administration.
Trazonil
side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Trazonil
Patient Information
Trazonil
Organisms Affected
Humans and other mammals