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Trialodine Brand names, Trialodine Analogs

Trialodine Brand Names Mixture

  • No information avaliable

Trialodine Chemical_Formula


Trialodine RX_link

Trialodine fda sheet

Trialodine FDA

Trialodine msds (material safety sheet)

Trialodine Synthesis Reference

Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)

Trialodine Molecular Weight

371.864 g/mol

Trialodine Melting Point

86-87 oC

Trialodine H2O Solubility

Sparigly soluble

Trialodine State


Trialodine LogP


Trialodine Dosage Forms


Trialodine Indication

For the treatment of depression.

Trialodine Pharmacology

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.

Trialodine Absorption

Well absorbed following oral administration.

Trialodine side effects and Toxicity

LD50=96mg/kg (i.v. in mice)

Trialodine Patient Information

Trialodine Organisms Affected

Humans and other mammals