Trialodine
Trialodine Brand names, Trialodine Analogs
Trialodine Brand Names Mixture
- No information avaliable
Trialodine Chemical_Formula
C19H22ClN5O
Trialodine RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Trialodine fda sheet
Trialodine msds (material safety sheet)
Trialodine Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Trialodine Molecular Weight
371.864 g/mol
Trialodine Melting Point
86-87 oC
Trialodine H2O Solubility
Sparigly soluble
Trialodine State
Solid
Trialodine LogP
2.553
Trialodine Dosage Forms
Tablet
Trialodine Indication
For the treatment of depression.
Trialodine Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Trialodine Absorption
Well absorbed following oral administration.
Trialodine side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Trialodine Patient Information
Trialodine Organisms Affected
Humans and other mammals
