Trazalon
Trazalon Brand names, Trazalon Analogs
Trazalon Brand Names Mixture
- No information avaliable
Trazalon Chemical_Formula
C19H22ClN5O
Trazalon RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Trazalon fda sheet
Trazalon msds (material safety sheet)
Trazalon Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Trazalon Molecular Weight
371.864 g/mol
Trazalon Melting Point
86-87 oC
Trazalon H2O Solubility
Sparigly soluble
Trazalon State
Solid
Trazalon LogP
2.553
Trazalon Dosage Forms
Tablet
Trazalon Indication
For the treatment of depression.
Trazalon Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Trazalon Absorption
Well absorbed following oral administration.
Trazalon side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Trazalon Patient Information
Trazalon Organisms Affected
Humans and other mammals
