Trazodone Hydrochloride

Trazodone Hydrochloride Brand names, Trazodone Hydrochloride Analogs

Trazodone Hydrochloride Brand Names Mixture

No information avaliable

Trazodone Hydrochloride Chemical_Formula

C₁₉H₂₂ClN₅O

Trazodone Hydrochloride RX_link

http://www.rxlist.com/cgi/generic/traz.htm

Trazodone Hydrochloride fda sheet

Trazodone_Hydrochloride FDA

Trazodone Hydrochloride msds (material safety sheet)

Trazodone Hydrochloride Synthesis Reference

Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)

Trazodone Hydrochloride Molecular Weight

371.864 g/mol

Trazodone Hydrochloride Melting Point

86-87 ^oC

Trazodone Hydrochloride H₂O Solubility

Sparigly soluble

Trazodone Hydrochloride State

Solid

Trazodone Hydrochloride LogP

2.553

Trazodone Hydrochloride Dosage Forms

Tablet

Trazodone Hydrochloride Indication

For the treatment of depression.

Trazodone Hydrochloride Pharmacology

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.

Trazodone Hydrochloride Absorption

Well absorbed following oral administration.

Trazodone Hydrochloride side effects and Toxicity

LD₅₀=96mg/kg (i.v. in mice)

Trazodone Hydrochloride Patient Information

Trazodone Hydrochloride Organisms Affected

Humans and other mammals