Trazodone
Trazodone Brand names, Trazodone Analogs
Trazodone Brand Names Mixture
- No information avaliable
Trazodone Chemical_Formula
C19H22ClN5O
Trazodone RX_link
http://www.rxlist.com/cgi/generic/traz.htm
Trazodone fda sheet
Trazodone msds (material safety sheet)
Trazodone Synthesis Reference
Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)
Trazodone Molecular Weight
371.864 g/mol
Trazodone Melting Point
86-87 oC
Trazodone H2O Solubility
Sparigly soluble
Trazodone State
Solid
Trazodone LogP
2.553
Trazodone Dosage Forms
Tablet
Trazodone Indication
For the treatment of depression.
Trazodone Pharmacology
Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.
Trazodone Absorption
Well absorbed following oral administration.
Trazodone side effects and Toxicity
LD50=96mg/kg (i.v. in mice)
Trazodone Patient Information
Trazodone Organisms Affected
Humans and other mammals
