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Trazodone Brand names, Trazodone Analogs

Trazodone Brand Names Mixture

  • No information avaliable

Trazodone Chemical_Formula


Trazodone RX_link

Trazodone fda sheet

Trazodone FDA

Trazodone msds (material safety sheet)

Trazodone Synthesis Reference

Palazzo, Silvestrini, U.S. Pat 3,381,009 (1968)

Trazodone Molecular Weight

371.864 g/mol

Trazodone Melting Point

86-87 oC

Trazodone H2O Solubility

Sparigly soluble

Trazodone State


Trazodone LogP


Trazodone Dosage Forms


Trazodone Indication

For the treatment of depression.

Trazodone Pharmacology

Trazodone is an antidepressant and hypnotic chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents. The mechanism of trazodone's antidepressant action in man is not fully understood. In animals, trazodone selectively inhibits serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan. Cardiac conduction effects of trazodone in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. In man, trazodone is well absorbed after oral administration without selective localization in any tissue. Since the clearance of trazodone from the body is sufficiently variable, in some patients trazodone may accumulate in the plasma.

Trazodone Absorption

Well absorbed following oral administration.

Trazodone side effects and Toxicity

LD50=96mg/kg (i.v. in mice)

Trazodone Patient Information

Trazodone Organisms Affected

Humans and other mammals