Racemorphanum [Inn-Latin]
Brand names,
Racemorphanum [Inn-Latin]
Analogs
Racemorphanum [Inn-Latin]
Brand Names Mixture
Racemorphanum [Inn-Latin]
Chemical_Formula
C17H23NO
Racemorphanum [Inn-Latin]
RX_link
http://www.rxlist.com/cgi/generic2/levorphanol.htm
Racemorphanum [Inn-Latin]
fda sheet
Racemorphanum [Inn-Latin]
msds (material safety sheet)
Racemorphanum [Inn-Latin]
Synthesis Reference
Woods LA, et al. J Pharmacol Exp Ther. 1958 Sep;124(1):1-8.
Racemorphanum [Inn-Latin]
Molecular Weight
257.371 g/mol
Racemorphanum [Inn-Latin]
Melting Point
198-199 oC
Racemorphanum [Inn-Latin]
H2O Solubility
1840 mg/L
Racemorphanum [Inn-Latin]
State
Solid
Racemorphanum [Inn-Latin]
LogP
3.986
Racemorphanum [Inn-Latin]
Dosage Forms
Tablet
Racemorphanum [Inn-Latin]
Indication
For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate
Racemorphanum [Inn-Latin]
Pharmacology
Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.
Racemorphanum [Inn-Latin]
Absorption
Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.
Racemorphanum [Inn-Latin]
side effects and Toxicity
LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.
Racemorphanum [Inn-Latin]
Patient Information
No information avaliable
Racemorphanum [Inn-Latin]
Organisms Affected
Humans and other mammals