Dea No. 9733
Brand names,
Dea No. 9733
Analogs
Dea No. 9733
Brand Names Mixture
Dea No. 9733
Chemical_Formula
C17H23NO
Dea No. 9733
RX_link
http://www.rxlist.com/cgi/generic2/levorphanol.htm
Dea No. 9733
fda sheet
Dea No. 9733
msds (material safety sheet)
Dea No. 9733
Synthesis Reference
Woods LA, et al. J Pharmacol Exp Ther. 1958 Sep;124(1):1-8.
Dea No. 9733
Molecular Weight
257.371 g/mol
Dea No. 9733
Melting Point
198-199 oC
Dea No. 9733
H2O Solubility
1840 mg/L
Dea No. 9733
State
Solid
Dea No. 9733
LogP
3.986
Dea No. 9733
Dosage Forms
Tablet
Dea No. 9733
Indication
For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate
Dea No. 9733
Pharmacology
Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.
Dea No. 9733
Absorption
Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.
Dea No. 9733
side effects and Toxicity
LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.
Dea No. 9733
Patient Information
No information avaliable
Dea No. 9733
Organisms Affected
Humans and other mammals