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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C17H23NO
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RX_link
http://www.rxlist.com/cgi/generic2/levorphanol.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Woods LA, et al. J Pharmacol Exp Ther. 1958 Sep;124(1):1-8.
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Molecular Weight
257.371 g/mol
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Melting Point
198-199 oC
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H2O Solubility
1840 mg/L
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State
Solid
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LogP
3.986
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Dosage Forms
Tablet
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Indication
For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate
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Pharmacology
Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.
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Absorption
Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.
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side effects and Toxicity
LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals